Henry Horng-Shing Lu (¿cÂE¿³)

Institute of Statistics
National Chiao Tung University

Fall, 2007

Tel: 03-5731870 Email: hslu@stat.nctu.edu.tw

Goals:

The course will introduce statistical methods in bioinformatics. Biological applications, statistical models and computation methods will be introduced through examples and software. Undergraduate knowledge of probability and statistics will be helpful for the understanding of this course. Related materials will be post at the course web page in http://www.stat.nctu.edu.tw/people/bio.php?PID=16.

Course Outlines:

• Biological Background
• Sequence Alignment and Analysis
• Microarray Data Analysis
• Protein Data Analysis
• Phylogenetics and Evolution
• Systems Biology

Reference Books:

• Richard C. Deonier, Simon Tavare, and Michael S. Waterman, Computational Genome Analysis: An Introduction, Springer, 2005.
• Warren J. Ewens and Gregory R. Grant, Statistical Methods in Bioinformatics: An Introduction, Second Edition. Springer, 2005.
• Andrzej Polanski and Marek Kimmel, Bioinformatics, Springer, 2007.
  Emmanuel Paradis, Analysis of Phylogenetics and Evolution with R, Springer, 2006.

Evaluation:

• In Class Discussion and Presentation: 30%
• Term Project: 70%

Links:

• Local links of statistical computing and statistics at http://www.stat.nctu.edu.tw/misg/hslu/course/statcomp/links.htm
• R software
• Virtual library of statistics at http://www.stat.ufl.edu/vlib/statistics.html
• Local links to bioinformatics at http://www.stat.nctu.edu.tw/misg/bioinformatics/index.htm
• NCBI: National Center for Biotechnology Information
• Links related to Functional Genomics